3-O-(2，3-二甲基丁酰基)-13-O-十二烷酰基巨大戟二萜醇

3-O-(2，3-二甲基丁酰基)-13-O-十二烷酰基巨大戟二萜醇

3-O-(2,3-dimethylbutanoyl)-13-O-decanoylingenol   CAS: N.A     分子量：660.46       分子式：C39H64O8

纯       度：      HPLC98%
物理性状：     油状液体
检测方法：     高效液相（HPLC）质谱（Mass) 核磁（NMR)
用      途：      仅供研究使用,不得用于医学诊断。
包      装：      20mg~1g 棕色玻璃瓶。
储存条件：     贮存在避光密闭容器中，冷藏或者冷冻长期保存。
样品溶液现配现用。如果特殊情况需要提前配制的话，最好分成独立包装冷冻保存（-20℃以下），临用前再取出解冻，通常可以保存2周。

植物来源
  大戟科植物甘遂EuphorbiakansuiT.N.LiouexT.P.Wang的干燥块根

药理研究

• 3-O-(2,3-dimethylbutanoyl)-13-O-decanoylingenol (DBDI)purified from the Euphorbia kansui L., inhibits degranulation in rat basophilic leukemia 2H3 cells upon aggregation of the FcepsilonRI. In the present study, we demonstrated that the DBDI significantly inhibits release of beta-hexosaminidase, synthesis of eicosanoids, and mobilization of intracellular Ca(2+) in the bone marrow-derived mouse mast cells stimulated with IgE and antigen. Furthermore, we revealed that phosphorylation of Syk, phospholipase C-gamma(2), and extracellular signal-related kinase 1/2 is significantly suppressed in the DBDI-treated mast cells. These findings suggest that the DBDI may have a therapeutic potential for allergic diseases by inhibiting intracellular signaling pathways for activation and chemical mediator release in mast cells.

• 大戟属植物作为大戟科植物最大的属,由于该属药用植物具有良好的抗肿瘤、抗白血病、抗菌、抗炎、抗病毒、抗结核等药理活性,

参考文献

• [1].  3-O-(2,3-Dimethylbutanoyl)-13-O-decanoylingenol from Euphorbia kansui Suppresses IgE-Mediated Mast Cell Activation [J].Bid Phann Bull,2006,29(2):286 290.

• [2] 包勒朝鲁 那生桑.大戟属药用植物的毒性及炮制减毒增效研究进展.世界科学技术[J]. 中医药现代化.2018年第20卷第4期 585-591